WebAlternatively, double Holliday junctions can be processed by a reaction known as “double Holliday junction dissolution.” This reaction requires the cooperative action of a so-called “dissolvasome” comprising a Holliday junction branch migration enzyme (Sgs1/BLM RecQ helicase) and a type IA topoisomerase (Top3/TopoIIIα) in complex with ... WebJun 30, 2005 · Double Holliday junction dissolution is specific for BLM. Despite the similar biochemical properties of many RecQ helicases in vitro, and their ability to act upon a wide variety of DNA structures, an elevated frequency of SCEs is thought to be a feature unique to BLM-deficient cells among human RecQ helicase mutants.
Dissolution of Double Holliday Junctions by the Concerted Action …
WebJul 9, 2014 · The dissolvasome complex collapses and unlinks a double Holliday junction DNA double-strand breaks can be repaired by homologous recombination, whose key intermediate is the four-way Holliday junction. During meiosis, Holliday junctions are cut by endonucleases to generate crossovers that are key to the proper segregation of … WebJul 9, 2014 · The dissolvasome complex collapses and unlinks a double Holliday junction DNA double-strand breaks can be repaired by homologous recombination, whose key … p buckley moss ohio star
Dissolution of double Holliday junctions by the concerted …
Webactivities include ATP-dependent Holliday junction migration, 3'-5' strand displacement, and ATP-independent single-strand annealing (9, 10). Most significantly, BLM protein in conjunction with topoisomerase IIIa (Top3a) can resolve double Holliday junctions (dHJs) via dissolution or convergent migration (11-14). WebJul 1, 2014 · Coronavirus: Find the latest articles and preprints ... WebDescription: Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA. Transcript (Including UTRs) Position: hg19 chr12:4,647,950-4,669,213 Size ... scriptures says as a man thinks in his heart