Tacc3 oocyte
WebJul 13, 2015 · TACC3 is expressed in oocytes and in early cleavage stage pre-implantation embryos. The expression of TACC3 mRNA in bovine oocytes and in vitro produced pre-implantation embryos was examined using qRT-PCR. TACC3 expression was detected at similar levels (p>0.05) throughout oocyte maturation and during the first cleavage stages … WebNov 18, 2024 · We found that mutations in TACC3 cause defects in spindle assembly by disrupting the structure of the huoMTOC, which leads to clinical oocyte maturation arrest. This suggests that the huoMTOC might be an important biomarker for evaluating the …
Tacc3 oocyte
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WebMay 1, 2002 · D-TACC is also requiredto efficiently recruit Msps to the poles of the acentrosomal meiotic spindles in oocytes, suggesting that these proteins can work together to regulate microtubule behaviour even when centrosomes are not present [25. ... Thus, perhaps the TACC3 −/ ... WebJun 2, 2024 · TACC3, a transforming acidic coiled-coil (TACC) family member, is frequently upregulated in a broad spectrum of cancers, including breast cancer. It plays critical roles in protecting microtubule stability and centrosome integrity that is often dysregulated in cancers; therefore, making TACC3 a highly attractive therapeutic target.
WebJul 13, 2015 · TACC3 mRNA was detected in bovine oocytes during meiosis using qRT-PCR, and while it was also expressed in cleavage stage embryos, its expression was down-regulated at the mor-ula and... WebApr 3, 2024 · TACC3 is related to biological progress (BP), cellular component (CC), and molecular function (MF). ... Alzheimer disease, oocyte meiosis, phagosome, cell cycle, cellular senescence, DNA replication, and progesterone-mediated oocyte maturation. The 2 most negatively related categories included lysosome and human T cell leukemia virus 1 ...
WebRecently, the human oocyte microtubule organizing center was found to be a driver for spindle assembly in human oocytes, and deficiencies in TACC3, the key component of this center, were shown to impair microtubule nucleation and meiotic spindle assembly, leading to nuclear maturation arrest . WebThe expression levels of several microtubuleassociated proteins including TACC3, KIF14 and ASPM were also reduced in the aging oocytes. ... Proteomic analysis implicates that postovulatory...
WebTransforming acidic coiled-coil (TACC) proteins are key players during mitosis via stabilization of the spindle. The roles of TACCs during meiosis are however less clear. We used bovine oocytes...
WebAug 5, 2024 · TACC3, a member of the TACC family, is a dominant protein in this domain, which is essential to promote the formation of a highly dynamic liquid-like meiotic spindle domain (LISD) in mammalian oocytes (Peset and Vernos 2008; Wang et al. 2024). ls swapped mazda 3WebAug 5, 2024 · Notably, IPZ treatment decreased TPX2 expression and abnormal subcellular localization. Furthermore, the expression levels of aurora kinase A (AURKA) and transforming acidic coiled-coil 3 (TACC3)... ls swapped s13WebFeb 18, 2024 · 3.4 Oocyte and granulosa cell communications We used iTALK to characterize the L-R–mediated intercellular communication and list the top 100 L-R pairs in antral stage oocytes and GCs (Table S2 ). Figure 3A … ls swapped cj5WebMar 1, 2024 · Spindle assembly defects mediated by centrin TACC3 and decreased acetylation, microfilament reorganization failure, and mitochondrial dysfunction were found to be the underlying mechanisms involved in the toxicity of cobalt chloride to oocytes. ls swapped challengerWebNov 1, 2002 · A protein spot cored from a silver-stained two dimensional (2D) gel of germinal vesicle stage immature mouse oocytes was identified as Transforming Acidic Coiled Coil containing protein (TACC3)... jcpenney women\u0027s wedge shoesWebJul 13, 2015 · As a result of the embryonic lethality, the function of TACC3 during oocyte meiosis remains unclear. Compared to mitosis, little is known about the mechanisms that drive and control meiosis in oocytes. Here, we show that TACC3 is expressed around the … ls swapped trans am for saleWebSep 19, 2005 · TACC3 enhances the number of microtubules emanating from mitotic centrosomes, and its targeting to centrosomes is regulated by Aurora A–dependent phosphorylation. We propose that Aurora A regulation of TACC3 activity defines a centrosome-specific mechanism for regulation of microtubule polymerization in mitosis. … jcpenney women\u0027s underwear on sale