Redox sumoylation
Web12. aug 2024 · Nor1 SUMOylation impaired gene transcription through less effective Nor1 chromatin binding and reduced enrichment of histone H3K27ac marks to gene promoters. These effects resulted in decreased neuronal cell growth, increased apoptosis, and reduced survival to oxidative stress damage, underlying the role of pSuM-modified Nor1 in redox … Web7. mar 2014 · In this work, we report that redox-dependent induction of p53 transcriptional activity is enhanced by the oxidative stress-induced SUMOylation of TP53INP1 at lysine …
Redox sumoylation
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Web6. dec 2024 · In this study, we aimed at detecting whether nNOS is a target protein of SUMOylation in the hippocampus and its contributions to hippocampal long-term … Web30. jan 2024 · Reversible post-translational protein modification by small ubiquitin-like modifier (SUMO), sumoylation, is a crucial mechanism in the maintenance of genomic integrity, in the regulation of...
Web23. dec 2014 · Sumoylation of TP53INP1 on the K113 residue, which is mediated by protein inhibitor of activated STAT 3 (PIAS3) and chromobox homolog 4 (CBX4) and removed by … Web19. nov 2024 · SUMOylation of IDH2 which could be induced by oxidants treatment enhances the activity of IDH2 to protect cells against oxidative stress. These results …
Web8. apr 2024 · Co-expression of p85β WT or p85β SUMOylation mutant led to a reduction in p110β SUMOylation (Fig. 5b, left panel). In addition, we also observed a reduction in the SUMOylation of p110β after transfection of increasing amounts of the p85β SUMOylation mutant (Fig. 5b, right panel). These results suggest that p85β modulates the covalent ... Web28. júl 2024 · SUMOylation and deSUMOylation are dynamically balanced in the maintenance of various biological processes including cell division, DNA repair, epigenetic …
Web19. okt 2024 · Fig. 1: SUMOylation: a tightly balanced attachment of SUMOs to substrates. Small ubiquitin-like modifier (SUMO) proteins 1–3 undergo a maturation step, followed by an ATP-dependent SUMO transfer...
Web31. júl 2014 · SUMOylation is a highly dynamic process, where deconjugation (deSUMOylation) is catalyzed by a family of cysteine proteases, termed SUMO-specific proteases or SUMO isopeptidases. A subset of these enzymes also functions in processing of the SUMO precursor proteins, which is a prerequisite for their conjugation. father john therry schoolWebA redox reaction is a chemical reaction in which the atoms change their oxidation numbers. Some atoms lose electrons and are oxidized – a process known as oxidation. On the … fresno state field dayWebSumoylation of TP53INP1 on the K113 residue, which is mediated by protein inhibitor of activated STAT 3 (PIAS3) and chromobox homolog 4 (CBX4) and removed by SUMO1/sentrin specific peptidase (SENP1, 2 and 6), favors its interaction with TP53 in the nucleus and enhances TP53-induced gene expression. Abbreviations Commentary … fresno state fieldWebredox homeostasis. Interestingly, posttranslational protein modifications (PTMs) play a remarkable role. In fact, several target proteins are modified in their activation, … fresno state fitness centerWeb24. jún 2024 · Sumoylation is an essential post-translational modification that is catalysed by a small number of modifying enzymes but regulates thousands of target proteins in a … fresno state finals schedule spring 2022WebSumoylation of proteins linked to stem cell potential, such as PML/RARA, KAP1 or Polycomb complex member (PHC2), all decreased at later timepoints, likely reflecting their SUMO2 … fresno state financial aid and scholarshipsWebROS-induced acetylation of the proapoptotic kinase HIPK2 as a molecular mechanism that controls the threshold discerning sensitivity from resistance toward ROS-mediated cell death. SUMOylation of HIPK2 at permissive ROS concentrations allows the constitutive association of HDAC3 and keeps HIPK2 in the nonacetylated state. father john thomas lane