Peripherin
WebFeb 10, 2024 · It demonstrates that peripherin-2/rds (P/rds), a photoreceptor-specific protein associated with a broad range of inherited retinal diseases, shapes membranes to help build the distinctive architecture of photoreceptor OSs. More specifically, it reveals the normal function of P/rds as a curvature-generating protein that is essential for high ... WebApr 21, 2024 · Mutations in the PRPH2 gene encoding the photoreceptor-specific protein PRPH2 (also known as peripherin-2 or rds) cause a broad range of autosomal dominant retinal diseases. Most of these mutations affect the structure of the light-sensitive photoreceptor outer segment, which is composed of a stack of flattened “disc” …
Peripherin
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WebSee all Peripherin primary antibodies Description Mouse monoclonal [8G2] to Peripherin Host species Mouse Tested applications Suitable for: WB, ICC/IF more details Species reactivity Reacts with: Mouse, Rat, Cow, Human Immunogen Recombinant Rat Peripherin purified from E. coli. Positive control WebPeripherin is a neuronal intermediate filament protein that is expressed chiefly in motor neurons and other nerve cells that project into the peripheral nervous system. Transgenic mice that over-express peripherin develop motor neuron degeneration, suggesting that mutations in peripherin could contribute to the development of motor neuron disease.
Peripherin is a type III intermediate filament protein expressed mainly in neurons of the peripheral nervous system. It is also found in neurons of the central nervous system that have projections toward peripheral structures, such as spinal motor neurons. Its size, structure, and sequence/location of protein … See more Peripherin, first named such in 1984, was also known as 57 kDa neuronal intermediate filament prior to 1990. In 1987, a second distinct peripherally located retinal rod protein was also given the name peripherin. … See more Peripherin was discovered as being the major intermediate filament in neuroblastoma cell lines and in rat pheochromocytoma cells. … See more The complete sequence of the human (GenBank L14565), rat (GenBank M26232) and mouse (EMBL X59840) peripherin genes (PRPH) have been reported and complementary DNAs (cDNA) … See more Peripherin may be involved in the pathology of insulin-dependent diabetes mellitus (or diabetes mellitus type 1) in animals; however, no direct linkage has been found in … See more The diverse properties of intermediate filaments, compared with the conserved microtubule and actin filament proteins, could be responsible for the distinguishing molecular shapes of different cell types. In nerve cells, for example, the expressions of different types of … See more Protein and neurofilamentous aggregates are characteristic of patients with amyotrophic lateral sclerosis, a progressive, fatal neurodegenerative disease. Spheroids, specifically, which are protein aggregates of neuronal intermediate … See more Possible involvement of intermediate filaments such as peripherin in neurodegenerative diseases is currently being investigated. Interactions between intermediate filaments and other proteins are also being pursued. Peripherin has been shown to … See more WebApr 5, 2006 · Peripherin is a neuronal intermediate filament protein that is expressed chiefly in motor neurons and other nerve cells that project into the peripheral nervous system. Transgenic mice that over‐express peripherin develop motor neuron degeneration, suggesting that mutations in peripherin could contribute to the development of motor …
WebPeripherin is an important protein that regulates the formation and renewal of photoreceptor disc outer segments. It is an integral membrane protein consisting of 346 … WebMay 1, 2010 · Pattern dystrophy (PD) of the retinal pigment epithelium (RPE) refers to a heterogeneous group of dominantly inherited macular diseases characterized by the development of a variety of patterns of deposits of …
Webperipherin is a novel substrate for Akt in vivo and its phosphorylation may play a role in motor nerve regeneration; The data of this experiment document the expression of …
Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length. Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton. They are believed to function primarily to provide structural support for axons and to regulate axon diameter, which influences nerve conduction velocity. The proteins that form neuro… corepower utc scheduleWeb(this is different from peripherin 2 that is expressed in the retina). Thus mammalian neurofilaments are heteropolymers of up to five different proteins: NF-L, NF-M, NF-H, α-internexin and peripherin. The five neurofilament proteins can co-assemble in different combinations in different nerve cell types and at different stages of development. corepower victory parkWebSingeç and colleagues (Deng et al.) present a robust and reproducible sensory neuron differentiation method for human pluripotent stem cells that enable translational studies. … core power vanilla protein shake nutritionWebPeripherin 2 is found in the retina, the light-sensitive tissue that lines the back of the eye. This protein is essential for the normal function of specialized cells called photoreceptors … core power vs boostWeb4.外周蛋白（peripherin） 1. 波形蛋白（vimentin） 间质细胞（如成纤维细胞）的主要结构蛋白，C端尾 部特异地结合于细胞核外膜，N端头部结合细胞膜，故在 细胞核和细胞膜之间形成联接。 corepower waiverWebab106276, at 1/2000, staining Peripherin (green channel) and Neurofilament alpha-internexin/NF66 (green channel) in Rat mixed neuron/glial cultures by Immunofluorescence. These cultures contain mostly neurons which are rich in alpha internexin, and a subgroup which have a large amount of peripherin also, such as the prominent cell in the middle ... fancy dress with an eWeb产品编号：C001385. 品系背景：C57BL/6J. 繁殖：纯合×纯合 . 品系描述. 外周蛋白2（Peripherin 2, PRPH2）基因编码的蛋白质是四跨膜蛋白家族的成员，该家族蛋白中的大 … core power vanilla shake