SpletPC61 treatment, used to decrease Treg cell levels, did not change LCMV titers but resulted in a surprising decrease in lung pathology upon LCMV infection in IAV-immune but not in naive mice. Associated with this decrease in pathology was a retention of Treg in the mLN and an unexpected partial clonal exhaustion of LCMV-specific CD8(+) T-cell ... SpletThe PC61 monoclonal antibody specifically binds to CD25, the low-affinity IL-2 Receptor α chain (IL-2Rα, p55) expressed on activated T and B lymphocytes from all mouse strains tested. IL-2Rα by itself is not a signaling receptor. However, it can combine with IL-2 Receptor β (CD122) and γc (CD132) chains to form high-affinity, signaling receptor …
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SpletFresh, frozen mouse spleen was stained with purified CD25 clone PC61 conjugated and detected with a Cy5 CODEX™ oligonucleotide duplex (red). Samples were counterstained with TCR FITC (green). Data generated at Akoya Biosciences, Inc. using the CODEX™ technology. Compare all formats Cat # Size SpletDepletion of CD4 + CD25 + FoxP3 + Treg using PC61 mAb (anti-murine CD25 rat IgG1) is widely used to characterize Treg function in vivo.However, the mechanism of Treg depletion remains largely unknown. Herein, we report the PC61 mAb's mechanism of action. In peripheral blood, a single injection of PC61 mAb eliminated ∼70% of CD4 + FoxP3 + cells … SpletEssential Tee PC61 S-6XL 6.1-ounce, 100% soft spun cotton 98/2 cotton/poly (Ash) 90/10 cotton/poly (Athletic Heather) 50/50 cotton/poly (Dark Heather Grey) Removable tag for comfort and relabeling 1×1 rib knit collar Shoulder to shoulder back neck tap hrblock fallon nv