2024 Meg3 gene function

Meg3 gene function

Author: zbvp

August undefined, 2024

Web27 okt. 2024 · We aim to investigate the roles and mechanisms of long non-coding RNA maternally expressed gene 3 (lnc-MEG3) in NPC. Methods. The expression levels of lnc-MEG3 and sequestosome 1 (SQSTM1) in NPC tissues and cell lines were detected by quantitative real-time polymerase chain reaction (qRT-PCR). WebMEG3 HGNC:14575 55384 (Entrez Gene) 605636 MEG3 (Alliance of Genome Resources) Chr14 q32.2: Chr14:100826108-100861026 (+) GRCh38.p7: NM_018514 : mouse: Meg3: MGI:1202886 17263 (Entrez Gene) Gene Tree Meg3 (Alliance of Genome Resources) Chr12 60.25 cM

Long Noncoding RNA MEG3 Interacts with p53 Protein and …

Web21 mrt. 2024 · This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in … WebMaternally expressed gene 3 (MEG3), located on human chromosome 14q32, is a maternally expressed imprinted gene expressed in many normal tissues. 12 It has been … drayton swimming baths

The Effect of Metformin and Carbohydrate-Controlled Diet on …

WebMaternally Expressed Gene 3 (MEG3) is a long noncoding RNA (lncRNA) that coordinates a diverse array of cellular processes requiring epigenetic regulation of genes and interactions with key signaling proteins and by acting as a competitive endogenous (ce)RNA. Epigenetic modifications driven by in utero nutrition affect MEG3 expression and its role in the … WebAdditionally, we demonstrate that an evolutionarily conserved intronic region at the MEG3 locus can function as an enhancer in βTC6 β-cells. Using … WebFurthermore, Meg3 relied on functional enhancer of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), to inhibit c-Met expression. Another mechanism of lncRNA-mediated regulation of gene expression utilized triplex-forming GA … ems collision alberta

The Biological Roles and Molecular Mechanisms of Long Non …

Activation of p53 by MEG3 Non-coding RNA*

WebMEG3functions an important role in the regulation of proper cell growth and embryo development and therefore may be a putative tumor suppressor gene, because one of its functions is to activate p53 and inhibit cell proliferation. WebAlthough thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5′- and 3′-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternally expressed gene 3 … ems college of paramedical sciencesWebView unique variants in gene MEG3 View all variants in gene MEG3 Full data view for gene MEG3 Create a new data submission View active genomic custom columns Enable more genomic custom columns View all individuals View all individuals with variants in gene MEG3 Create a new data submission View active custom columns Enable more custom … draytons wines cellar door

"WebThe MEG3 gene encodes a non-coding RNA that functions to suppress tumor cell growth and increase protein expression of the tumor suppressor p53, and … " - Meg3 gene function

Meg3 gene function

Web9 mrt. 2024 · MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with PDCD4 mRNA for directly binding to miR-21, which mediates … Web1 apr. 2024 · Maternally expressed gene 3 (MEG3) ... Implications: MEG3 functions as a tumor-suppressive lncRNA and aberrant promoter hypermethylation is critical for MEG3 gene silencing in ESCC.

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Web1 feb. 2024 · The hypothesis that exosomal MEG3 in urine can be used as a novel diagnostic biomarker for Hunner‐type interstitial cystitis is verified. Toll‐like receptor‐7 (TLR7) is functionally involved in the pathogenesis of Hunner‐type interstitial cystitis (HIC). In addition, maternally expressed gene 3 (MEG3) is implicated in many urethral diseases. … Web21 mrt. 2024 · Gene functional enrichment analysis. For DEGs, gene ontology (GO) analysis was performed with R package cluster Profiler (v4.0.2) . ... but more effort need to be made to characterize the functional implication of Meg3 in interneurons for cognitive impairment and epileptic seizure of anti-NMDAR encephalitis.

WebLong non-coding RNA (lncRNA) MEG3 is a key biomarker and therapeutic target in lung cancer; however, its underlying molecular mechanism in lung cancer progression remains unclear The present study demonstrated a novel regulatory axis in lung cancer, lncRNA MEG3/dyskeratosis congenita 1 (DKC1), and further investigated the effects and … Web14 feb. 2024 · Meg3 has been shown to play an important role in the regulation of cellular proliferation and functions as a tumor suppressor in numerous tissues. Meg3 is highly …

Web1 nov. 2003 · The MEG3 cDNA isoform MEG3a (see Fig. 1A for sequence), obtained from the library screening, was cloned into pCI-neo (Promega, Madison, WI) via the 5′-EcorRI … WebLong noncoding RNAs (lncRNAs) function in various biological processes (), including stem cell differentiation (), cell fate determination (), parental imprinting (), tumorigenesis (), and immune response (). lncRNAs can facilitate or disrupt protein-protein interactions and directly bind to DNA and RNA to regulate gene expression and transcript abundance, …

Web21 feb. 2024 · The present review highlights biological function of MEG3 to repress tumor through regulating the major tumor suppressor genes p53 and Rb, inhibiting angiogenesis-related factor, or controlling miRNAs. On the other hand, previous studies have also suggested that MEG3 mediates epithelial-mesenchymal transition (EMT).

Web6 apr. 2024 · Preliminary findings suggest that metformin and a carbohydrate-controlled diet improve endometrial function in PCOS patients, partly by modulating DNA methylation of the HOXA10 gene promoter and the expression of genes implicated inendometrial receptivity and insulin signaling. Polycystic ovary syndrome (PCOS) is an endocrine … emsco grow boxWeb24 jul. 2015 · Here we show that MEG3 and EZH2 share common target genes, including the TGF-β pathway genes. Genome-wide mapping of MEG3 binding sites reveals that … ems college kimberleyWeb15 feb. 2024 · growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 50- and 30-rapid ampliﬁcation of cDNA ends (RACE) assays, we obtained two di erent variants of lncRNA maternally expressed gene 3 (MEG3), namely, MEG3 draytons wolverhamptonWeb8 okt. 2024 · The maternally expressed gene 3 ( MEG3) was the first lncRNA proposed to have a tumor suppressor function ( 10, 11 ). Using cDNA-representational difference analysis, MEG3 expression was not detected in either pituitary tumors, when compared to normal human pituitary tissue, nor in several human cancer cell lines ( 10 ). emsco hypercoolWebMEG3 is a maternally expressed imprinted gene suggested to function as a non-coding RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The tumor suppressor p53 plays a central role in tumor suppression and mediates the functions of many other tumor suppressors. Therefore, we hypothesized that MEG3 functions … drayton switchmasterWeb1 dec. 2024 · MEG3 could function as a molecular scaffold linking different proteins and forming large complexes that regulate chromatin structure and gene expression. By interacting with the RNA binding domain of Jumonji and AT-rich interaction domain containing 2 (JARID2), MEG3 stimulates PRC2 and JARID2 assembly, thereby … ems collaborationWeb2 apr. 2012 · MEG3 induces accumulation of p53 (TP53) protein, stimulates transcription from a p53-dependent promoter, and selectively regulates p53 target gene expression. … ems collombey