Web14 nov 2024 · Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules. The shape-forming feature of single-stranded oligonucleotides provides high affinity and excellent specificity toward targets. Hence, aptamers can be used as analogs of antibodies. In December 2004, the US Food and Drug Administration … WebAptamer-Drug Conjugates. Toward the next generation of smart anti-tumor drugs: a highly water-soluble nucleolin aptamer-paclitaxel conjugate with a serum-stable linker for tumor …
Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting …
WebAs a Senior Research Scientist you will be an integral part of our R&D team, which primarily focus on the development of point-of-care electrochemical aptamer-based sensors (E-AB) for drug monitoring and various other applications. You will focus on the construction techniques of E-AB biosensors, experimental verification and optimization of E ... Web28 mag 2024 · Aptamer Group, the developer of diagnostic and therapeutic Optimer™ reagents, today announced that it has signed an agreement with the multinational … the effects of tango on argentine society
A photo-activated aptamer–drug conjugate for targeted drug …
Web14 apr 2024 · Staphylococcal enterotoxin B (SEB) is a protein produced by Staphylococcus aureus, which is toxic to humans. It is well known for its ability to stimulate the exacerbated activation of proinflammatory CD4+ T cells (Th1 profile), and in vitro studies have been conducted to understand its mechanism of action and its potential use as an immune … Web12 gen 2024 · The aptamer-based sensor consists of an aptamer labeled with methylene blue (gold sphere) and tethered to an electrode. Binding of the target molecule (the antibiotic kanamycin shown here) causes ... WebThe aptamer, a single, short nucleic acid sequence that can specifically bind with many targets, was an anti-ATP aptamer. Two DNA sequences were designed: i) a functional chain (Chain A) consisting of two parts, i.e., the anti-ATP aptamer (recognition part) and the DNAzyme (signal transduction part) and ii) a blocker chain (Chain B), which could … the effects of sports gambling